Mobile lifting jack is one of the key equipment necessary for the maintenance base of EMU. At present, manual mobile lifting jack is the most widely used. The mobile lifting jack is mainly composed of frame, transmission device, bracket part, base and other parts. The frame is the main bearing part, and its safety and stability have an important impact on the normal use of the whole mobile lifting jack. In this paper, Pro/E, ANSYS and other modern engineering software platform are used to analyze the stress, strain and buckling mode on the frame of JC-17B mobile lifting jack. The results show that the maximum equivalent stress of the frame 3000mm away from the rail surface is 107.927MPa, which meets the strength requirements. The first and second order vibration frequencies of the frame are low, close to the frequency of the vibration source, and there is a danger of resonance, so try to avoid it. The research results provide a reliable theoretical basis for the development, technical transformation and equipment update of various types of frame in the future.