Until now, studies in Egypt have not focused on investigating the mediating role of open innovation in the relationship between organizational justice and organizational pride in any sector. This study employed social exchange theory to examine the role of open innovation in the joint relationship between organizational justice and organizational pride. Using Smart PLS and PROCESS macro, the analysis of data obtained from 275 employees in the Egyptian healthcare sector revealed a positive impact of organizational justice on organizational pride. Furthermore, there was a positive impact of organizational justice on the implementation of open innovation. The study also demonstrated the positive mediating role of open innovation in the relationship between organizational justice and organizational pride.