This paper explores how big data promotes discipline construction in colleges. We takes the 42 “First-Class Universities” in China as the research object. Based on the perspective of bibliometrics, contents related to “Discipline Construction” in the construction scheme of universities were analyzed with the help of ROST software. Through word frequency statistics, the high-frequency hot words of first-class discipline construction were obtained. On this basis, the keyword correlation analysis and keyword coding were carried out respectively to form the high-frequency word network association diagram and discipline construction concept model of “First-Class Universities”. Finally, with the characteristics of big data, this paper puts forward the thinking of discipline construction in the information age.