With the development of science and technology, the process of urbanization is accelerating, and many structures are developing towards the trend of large-scale. The emergence of large-scale structures such as aircraft, buildings and bridges provides a more comfortable and convenient living space for human beings, but there are also some mechanical problems in the design and manufacturing process of these large-scale structures. For example, due to the influence of size, wind load, earthquake and other load forms will have a great impact on the structure. According to the above requirements, this paper designs a structural vibration reduction design based on tuned mass damper (TMD), and analyzes its application effect. The analysis results show that this design method is a simple, effective and economical control method, which can effectively reduce the acceleration and displacement of large-scale structures under vibration.