The internal structure of semi-flexible pavement (SFP) is prone to fatigue damage, which affects its service life. The cement mortar admixture has a crucial influence on the fatigue resistance of SFP. In order to explore and study the fatigue resistance performance of SFP, Waterborne Epoxy Resin, emulsified asphalt and Carboxyl Latex were selected as cement mortar admixtures to prepare special cement mortar, and the effect of admixtures on the fatigue resistance of SFP was evaluated by indirect tensile fatigue test. The tests show that Waterborne Epoxy Resin undermines the fatigue resistance of SFP, while emulsified asphalt and Carboxyl Latex can improve it.