In order to realize the real-time simulation of regional integrated energy system, a multi-energy flow collaborative real-time simulation technology based on message bus is proposed, and the real-time simulation platform established on this basis realizes the real-time simulation of electrical and thermal systems. By using the co-simulator composed of message-oriented middleware and adapter to coordinate multiple simulators to complete the real-time simulation of the system in the loop, the message bus uses the open source ZeroMQ; it provides a unified message subscription and message publishing mechanism for all real-time simulators. Adapters are used to connect a variety of heterogeneous emulators, such as RT-LAB, TRNSYS, etc., to messaging middleware. Adopting message-oriented middleware and adapter scheme, it has the characteristics of open and extensible. The simulation system developed in this paper can be used in the real time simulation of distribution integrated energy system to realize the interaction between energy flow and information flow.