This work presents an old and new approach for Cybersecurity. The old one, Defense-in-Depth approach was developed in 2002 by the U.S. DoD, and promulgated by the National Security Agency. This old approach is still effective in the present circumstances using the Hybrid Architectures for the On-Premises and Cloud Computing. Another approach by Data-Centric or Data-driven was radically expanding under the edge technologies such as Big Data Analytics or Machine Learning. The Defense in Depth approach is the basic and valuable concept for the Cyber Defense. But some Information Technology staffs were misleading and degrading this concept into the technology-specific aspects, such as “Multi-layered defense”. In the original concept, this approach includes People, Technology and Operation aspects. Then, we are working in the Cloud Computing Environments, so system or platform-centric approaches have lost their realities, and we must seek the new data-centricity in the Defense in Depth approach.