Article presents some empirical data on targeted killing/ assassination of the leaders and members of terrorists' and guerilla groups in the Afpak region 2004 - 2012 with the use of American Unmanned Aerial Vehicles (drones). I focus my attention on core al Qaeda and its affiliates as well as Taliban leadership assassinated through this program. I disregard in my paper the problems of both legal and moral judgment of targeted killings, concentrating attention on its growing efficiency and scope. It seems that attacks are based on precise and actionable intelligence resulting in its growing number and effectiveness. One can also presume that no more than 10% of the victims of these American attacks can be described as collateral damage. As a result planning and operational capabilities of terrorist groups, primarily al Qaeda central have been effectively limited. However, this statement is not precise as far as so called Taliban groups are concerned.