Human blood mononuclear cells (PBMC) were exposed to X-rays 0,1 Gy, to Microwaves 2850 MHz, SAR 0,1 W/kg or to the both exposures sequentially. In the microculture system functional properties of T lymphocytes and monocytes were tested and production of monokines (IL-1β, IL-1ra) was estimated. The irradiation protocols influenced differentially T cell response to mitogens (PHA, Con A), degree of saturation of IL-2 receptors, immunoregulatory T cell suppressive avtivity, monocyte immunogenic activity and monokine production. The administered irradiations have demonstrated immunotropic influence modulating the both T lymphocyte immunocompetent functions and monocyte immunogenic activity.