The rapid growth and development of information technologies over recent years, in the areas of mobile and wireless technologies is shaping a new technological scenario of telemedicine in diabetes. This telemedicine scenario can play an important role for further acceptance by diabetic patients of the existing continuous glucose monitoring systems and insulin pumps with the final goal of improving current therapeutic procedures. This paper describes a Personal Smart Assistant integrated in a multi‐access telemedicine architecture for the implementation of a mobile telemedicine closed‐loop system for diabetes management. The system is being evaluated within the European Union project named INCA (“Intelligent Control Assistant for Diabetes”).