Information system can be useful to effective and flexible decision making of nursing resource administration. A Nurse Resources Management Information Model and a Nurse Resources Management Information System (NRMIS) were developed in this study. The NRMIS consisted of a nursing staff scheduling system (NRS), a patient classification system (PCS), and an optimal nursing manpower estimating system (ONMES). The patient classification system was developed according to nursing intensity. The system was evaluated through user interface satisfaction and usefulness in the clinical settings. The main challenge is how we realize this information model to support evidence-based nursing resource administration.