During the last four years, the Greek research, technology and innovation policy marked a significant turn in favour of innovation and the creation of conditions for effectively linking economic and social development to the research activities of public institutions, while at the same time encouraging the establishment of RTD activities in business enterprises. The structural change undertaken has been supported by funding from national and community sources (regional and social funds) as well as by private funding expected to exceed 35% of the total budget. The model has its limits in fulfilling the “demand for knowledge” by the business and public sectors to produce and market new products and services.