A complex set of needs–the increased accessibility to and interest in health information, more respected patients' rights, advanced information technologies, and pressure to seek a cost-effective healthcare delivery—introduced the Personal Health Record (PHR). Nursing care, as essential to healthcare, must be represented in a PHR, but few studies have explored the nurses' role in the development and expansion of the PHR. Our ‘IOWA PERSONAL HEALTH RECORD (IowaPHR)’ would be a pioneer to demonstrate how nursing can be integrated in the PHR. IowaPHR is attributed with these innovations: (1) information that embraces main community health concerns; (2) transformation of a standardized nursing language into questions adjusted for consumer vocabulary level; and (3) a user-friendly interface equipped with trending of health conditions and a diary function. The usability of this PHR is validated by experts in terms of content, ease of navigation, time needed to complete tasks, ability to find desired information, and site presentation. This work will provide a way for nursing informatics to make a difference in health informatics.