This chapter introduces a systematic approach towards large-scale chain communication between autonomous organisations and professionals that cooperate to tackle social problems. This approach combines a specific chain perspective with a dynamic chain concept to better understand the complexities of large-scale social systems - with or without ICT – in a barely-manageable chain context. Many chain projects fail or falter and large-scale systems produce unexpected negative side-effects or even backfire. The example of the Dutch criminal law enforcement chain is used to explain how adversities and negative side effects can disrupt large-scale systems. This example stands as a model for other vital, large-scale systems, for instance identity management and health care. The underlying chain communication systems are important cornerstones of our future information society. Chain research at Utrecht University – now covering more than twenty chains in the Netherlands – has led to some valuable insights and breaking views that imply an ambitious agenda for public administration and information science.