The governments of Australia and the Netherlands have to deal with wicked problems, that cut across neat departmental boundaries and exceed the problem-solving capabilities of individual governmental institutions. In this chapter, we discuss how they dealt with two pressing problems (child abuse, immigration and integration) by adopting so-called joined-up or whole of government approaches to policy-making. These entail coming to new ways of organizing by decoupling traditional governmental structures. We explore how joined-up government works in practice, discuss its limitations and develop an agenda for further research.