Gridcole is a grid service-based tailorable collaborative learning system that provides two significant features. First, it enables the possibility of integrating tools that require supercomputing capabilities or specific hardware resources in order to support the collaborative learning situations in which this type of tools is required. Furthermore, it can interpret collaboration scripts created by educators in order to guide participants during the realization of collaborative learning situations. This chapter provides an overview of the system and describes a sample collaborative learning situation that can be supported by Gridcole with the purpose of illustrating its capabilities.