Enhancing the resilience of the high-tech manufacturing industry chain is significant to building a manufacturing powerhouse and promoting high-quality economic development. To quantitatively study the resilience of the high-tech manufacturing industry chain, a comprehensive evaluation index system is constructed from four dimensions: resistance, recovery, reorganization, and renewal. We measured the resilience of the high-tech manufacturing industry chain across 30 provinces in China from 2008 to 2022. The results indicate that while the resilience of this industry chain has been increasing annually, the overall level remains low, and there are significant regional disparities. To strengthen the resilience of the high-tech manufacturing industry chain, it is essential to improve original innovation capacity, promote digital transformation, and achieve coordinated regional development.