With the wide application of UAV technology in the power system, the information security of its acquisition terminal has become the key to ensure the stable operation of the system. Aiming at the deficiencies and challenges in existing research, this study systematically analyzes the information security risks faced by UAV collection terminals, including network attacks, hardware vulnerabilities and software vulnerabilities. Based on this, a set of multi-level and all-round information security protection strategy is proposed, covering the network layer, hardware layer and software layer. The network layer adopts firewall technology and intrusion detection and defense system, the hardware layer integrates hardware encryption module and adopts anti-jamming and reinforcement design, and the software layer focuses on security coding and auditing as well as security update and patch management. The proposed protection strategy is verified by constructing an experimental environment that simulates a power system, and the results show that it shows good results in coping with various types of attacks and significantly improves the information security of the UAV collection terminal. This study provides theoretical basis and practical guidance for the information security protection of UAV acquisition terminal in electric power system, which is of great significance for promoting the development of informatization and intelligence in electric power industry.