As a core element of Industry 4.0, intelligent manufacturing (IM) has influenced the direction of talent cultivation, and IM practice teaching has also become construction emphasis in various universities in recent years. The Center for Practice Innovations of Huazhong University of Science and Technology (HUST) relying on its strong mechanical discipline background and school enterprise advantages, has taken the lead in China in forming the IM practice education system guided by intelligence and driven by innovation. It has comprehensively summarized the measures and experiences in the construction of IM practical teaching platforms, practical teaching courses, and practical teaching modes. Through nearly five years of continuous improvement and practice, the Center for Practice Innovations has achieved the IM practice teaching covering various majors and four years of university, and has become a benchmark for the construction of IM practical platforms and practical courses in various universities.