With the rapid development of living standards and the leap up of national economy, the logistics industry has ushered in a vigorous development, which has played a great guiding role in promoting consumption and driving economic growth. To further expand their business and meet the different needs of customers, more and more enterprises have established many logistics distribution centers and applied a variety of car models to deliver different types of goods. Taking JD Logistics Company in Hubei Wuhan Province as an example, this paper has studied the optimization problem of multi-vehicle routing allocation, and gives corresponding solutions according to the actual situation of JD logistics in China based on scanning method and assignment model. The loading rate has been greatly improved and stabilized from 84.3% to about 95.5% based on the scanning method. The transportation time can reach to the minimum level based on the assignment model.