With the continuous development and promotion of IoT technology and products, problems such as “multiple, miscellaneous, and chaotic” have become prominent, which cannot meet the safety control needs of power grid infrastructure construction sites. The article proposes a cloud-edge collaborative IoT framework based on edge IoT agents. Firstly, by designing multimodal communication components and adopting standardized communication interfaces and protocols, standardized access to IoT devices and standardized collection and management of perception data were achieved. Secondly, a mechanism for cloud-edge collaboration was designed based on the IoT model on the IoT management platform. This framework effectively supports the application of power grid infrastructure business and enhances the safety management capability of construction sites. The article concentrates on on-site construction personnel and presents typical business application scenarios. The practicality and significance of the research results presented in the article are evident from the application situation.