With the development of the construction industry, curved and curved shapes are more and more favored by designers, so they are widely used in large public buildings such as hospitals and shopping malls. Combined with Jingzhou City central hospital engineering example, this paper points out that the safety reliability is the main consideration of stone curtain wall design, construction, the selection of stone principles and selection of dry pendant, the large radius arc dry hanging stone assumption T component, combined with the stress horizontal bending fatigue test results, from the anchor force deformation, anchor root force extension angle, curtain wall after arc stone unit force matrix using the equivalent strength factor analysis, demonstrate the arc thick stone curtain wall safety, hope to building similar arc building curtain wall construction has certain reference role.