This study considers 3D modeling to compare the seismic performance of hybrid control systems. The hybrid system in this research combines the usage of tuned mass dampers and seismic isolation. This seismic performance of this system is investigated under the effects of earthquakes and by considering soil-structure interaction. Analysis was performed by SAP2000 software. The dynamic analysis under earthquake effect was carried out by time domain analysis method. The example structure is symmetrical and has ten stories. The example building control cases are; fixed base conventional building, seismically isolated building, building incorporating tuned mass damper (TMD), and hybridly controlled building that combines the use of both seismic isolation and tuned mass damper. In these cases, numerical findings are obtained by considering soil-structure interaction. The results are presented comparatively for all different control and soil cases. It is obtained from this study that during the design of a building with isolators or TMD’s, soil-structure interaction should not be disregarded.