The paper presents new results of the full-scale measurements of waves and ship motions for the research vessel BIOS DVA offshore Split in the Adriatic Sea. Experiments were performed by measuring waves simultaneously and ship responses for five different heading angles and two ship speeds of 7 and 3.5 knots. Waves were recorded by a solar-powered floating buoy, while the ship motion was measured with an Inertial Measurement Unit. Time series of waves and ship motion were analyzed using the STATREL software, and a comparison of statistically and spectrally defined characteristics is presented. The new campaign was organized as the comparison of previous measurements with seakeeping calculations concluded that additional experiments were required to improve the accuracy of seakeeping predictions, especially for the mean zero up-crossing period in the following seas. Therefore, special attention is given to the motion in the following waves in addition to analyzing the influence of ship speed on responses.