In this paper, we provide an overview of Human-Computer Interaction (HCI) in the context of Artificial Intelligence (AI), focusing on Machine Learning (ML), Deep Learning (DL), Artificial Neural Networks (ANN), and applications of these techniques in the field of Healthcare. This review highlights the critical role of the human factor in AI-driven systems with discussions on AI ethics and expectations. Artificial Intelligence techniques, including ML and DL enhance gesture and speech recognition in HCI, while ANN models are particularly effective for hand gesture recognition. In Human-Computer Interaction, AI techniques bring value and understanding to Healthcare in real life. Despite the benefits that Artificial Intelligence brings to HCI, challenges remain. The future promises new applications and perspectives in HCI, where AI with ML, DL, and ANN have an effective impact.