In order to realize the innovation of the teaching mode of information management and information system profession, and better cultivate high-quality, application-oriented talents, the integration of student management system and education teaching in the background of multidisciplinary integration: strategy and practice. The article researches the teaching reform and practice of information management and information system specialty under the background of multidisciplinary integration. It analyzes the objectives and characteristics of information management and information system professional talents training, and puts forward the relevant measures of information management and information system professional teaching reform on this basis. The results show that after a period of teaching, most of the students in the class have good feedback on this teaching method.