Corrugated paperboard boxes are widely used as packaging in logistics processes. Corrugated boxes must have adequate strength to ensure proper protection of the product. In many cases, the product will require cutouts in the side walls of the boxes. These significantly affect the strength behavior of the box which can be determined by measurements and various models. The aim of this study is to determine the compressive strength of corrugated cardboard boxes of different sizes and different rectangle shaped cutouts formed on them. Five different box dimensions and five different cutout rates were investigated. Box compression tests were carried out to obtain the compression force result of the boxes. The results of these measurements were compared with the box compression force estimation formulas. Two types of McKee formula were used for the comparison that are commonly used in industry. The complete and the simplified McKee formulas are the used models in this study. The constant parameters for both McKee formulas was calculated for each cutout rates. For higher cutout ratios the accuracy of both the simplified and the complete McKee formula increases. In three groups at 0%, 4% and 16% cutouts the fitted complete and simplified McKee formulas predict the BCT results with significant differences. It can be observed that neither the complete nor the simplified McKee formula is able to account for changes in compression force due to variations in box size for any cutout category.