This paper is about a special configuration of engineering model and modeling platform for model development that serves widely connected research in applied informatics considering demands by highly automated achievements. Initiative for this special application of engineering modeling platform was motivated by engineering purposed software development towards reactive, autonomous, and widely contextual solutions to accommodate tasks in extending variety of integrated issues. After characterizing the multiphysical way of multidisciplinary model powered engineering research, this paper introduces novel model mediated scenario in which research specific engineering software related activities are placed with the emphasis on flexible model and software configuration considering composition of complex multidisciplinary solutions for multiphysical engineering representations and simulations those are extended to human organ and other bioinspired issues. Additional contributions in this paper are about capabilities of reactive autonomous models, extended representation of behaviors, and novel experimental model for research in applied informatics. Finally, application of the above experimental model in research using scientifically renewable world level engineering modeling platform at the Virtual Research Laboratory, and evaluation and advantages of the proposed research are introduced.