With the continuous development of computer network technology, the traditional manufacturing mode is only suitable for small workshop mode, and there is also the problem of information island, which is difficult to meet the needs of current intelligent factory system construction. This paper explores the application of artificial intelligence technology in mechanical manufacturing, and constructs an artificial intelligence model through practical cases. In order to improve the production management efficiency of enterprises and reduce production costs, manufacturing enterprises integrate advanced technologies such as information technology, automation technology, modern management technology and system science and technology into traditional manufacturing technology. The DNC and MES integrated system developed in this paper uses Ethernet technology and TCP/IP protocol to realize the communication between the system and field devices. Moreover, this study builds the verification environment based on the hardware environment of Window system workstation in the laboratory. By analyzing the experimental data, we can see that the artificial intelligence mechanical manufacturing simulation system proposed in this paper can effectively improve the efficiency and quality of mechanical manufacturing.