Aiming at the problem of the limited load of automated guided vehicle (AGV) used in logistics transportation, design a simple structure, safe and reliable AGV frame. The frame adopts seesaw structure to reduce the deviation of center of gravity, so that it can bear large load, and analyze its performance. The three-dimensional modeling of the AGV frame was created with SOLIDWORKS software and imported into HYPERWORKS for static analysis of full-load bending conditions, full-load bending and torsion conditions, emergency braking conditions, and emergency turning conditions to determine whether the strength and stiffness of the AGV frame meet the requirements, and according to the results of simulation for structural optimization. Then, the vibration characteristics of the frame structure were determined by free modal analysis through HYPERWORKS. The maximum stress and displacement of the AGV frame under four working conditions are obtained. Among which, the full-load bending and torsion condition is the most unfavorable. The maximum stress is 236.6MPa, which does not exceed the yield limit (343 MPa) of the material 16MnL. The maximum deformation is 1.413mm, which is within the allowable range. The natural frequency of the frame is between 10-46Hz, which belongs to the low-frequency range. The strength and stiffness of the AGV frame designed in this paper meet the requirements when the load is 3 tons, and there is no resonance phenomenon with the road surface. At the same time, it also provides certain ideas and reference value for designing other types of frames.