The backlog of pressure from multiple parties has led to a variety of psychological problems and has also led to many irreparable tragedies. It is very important for college student management to pay attention to the mental health problems of college students, and to discover and guide the mental health development of college students in time. This paper uses data mining technology to set up a questionnaire with 90 questions reflecting mental health as a sample. Using the “SCL-90 Symptom Self-Rating Scale” as the evaluation standard, data were collected, a data set was established, and data analysis was carried out, so as to detect and adjust psychological problems in time and avoid the aggravation of problems and lead to suicide and other irreversible problems.