In the article, the problems of management of the information support of regional technical and economic systems based on the digital technologies of the Industry 4.0 platform are defined and their relevance is justified. With the application of artificial intelligence technologies, some problems related to the effective management of information support in technical and economic systems, including innovative enterprises, were explained. Some aspects of the essence and activity of technical-economic systems and their information support were analyzed. An overview analysis of relevant scientific research works was conducted and the state of problem solving was studied. Digital technologies of Industry 4.0, as well as the main functions of artificial intelligence technologies, and some global development trends related to their application in various fields, were studied. An architectural-technological structure model was proposed based on the application of artificial intelligence technologies of technical-economic systems, as well as information support of innovative-industrial enterprises. In the conditions of the transfer of digital innovations, directions for increasing the sustainable activity of technical-economic systems and innovative enterprises have been determined. The level of importance of industrial-digital technologies applied in the activity of technical-economic systems and innovative enterprises is indicated. Based on artificial intelligence technologies, relevant recommendations were given on the mechanisms for solving the problems of management of the information support of technical and economic systems.