Engineering knowledge is an important step for creating innovative products. This paper discusses the morphological knowledge-based engineering (KBE). The development of science and technology is characterized by the increasing complexity of created technical means, a sharp increase in the cost of their development, production, operation, as well as rapid obsolescence. In this connection, the solution of the problem of creating machinery with a high technical level acquires special importance. A huge number of factors of structural, technological, operational, and economic nature, affecting the process of creating new equipment, predetermined the need to use system analysis and synthesis of knowledge in the synthesis of engineering systems. All this increases the number of possible implementations of both individual units and devices, and engineering systems. The need to improve the overall design methodology (and technological processes) is constantly increasing, which is a consequence of high rates of scientific and technological progress. Requirements for the maximum reduction of time spent on the entire cycle of creating a system or technological process have increased sharply. Morphological approaches correspond to these objective processes. They are considered in this paper and an example of the creation of an innovative aerostats system is given. The purpose of the article is to analyze the application of advanced morphological approaches. The approach is based on the application of set theory and agglomerative clustering of solutions. The paper describes the approach and results of using the proposed approach. As a result, the analysis and synthesis of innovative engineering solutions were carried out and recommendations for further development of the methodology were given. The use of the approach is considered as a continuous process of improving the technical level of engineering systems.