E-commerce systems have become one of the global trends in the current era when large-scale technological innovations are rapidly applied to all fields of activity. In particular, in recent times, the digital transformation of the economy and society has created conditions for the massive replacement of traditional trade with electronic trade. The rapid development of e-commerce has led to the emergence of many modern trends in the activity sectors, the formation of new requirements for e-commerce systems, and the beginning of a new era in logistics and supply chain management. An overview analysis of relevant scientific research works was conducted and the state of problem solving was studied. Providing a personalized approach to customers, optimizing supply chain operations, and responding to customer inquiries in a timely and accurate manner are the problems that await their solution. For this reason, in the presented article, directions for improving the performance of e-commerce systems and optimizing supply chain management processes by applying innovative technologies such as artificial intelligence, the Internet of Things, and big data have been studied. A conceptual model of intelligent e-commerce systems has been proposed based on the application of these technologies. Appropriate recommendations were given for modernizing e-commerce and logistics platforms applied at the national, regional, and enterprise levels based on new digital transformation technologies.