Ontario is shifting to a Precision Medicine (PM) model, which emphasizes tailored patient care, an initiative reflected in the formation of Ontario Health Teams. However, this shift faces significant data governance, policy formulation, and technology integration hurdles. To overcome these barriers, we advocate for a comprehensive PM framework to orchestrate collaboration among healthcare providers, policymakers, and technologists. This framework enhances data management, propels digital health innovations, and uphold ethical standards in AI applications. Effective deployment of this framework is crucial for actualizing PM’s promise in Ontario, potentially revolutionizing healthcare delivery.