The vehicle-mounted equipment installation frame and its key components may produce plastic deformation and fracture due to the gravity and vibration of the equipment in the process of road transportation. In this paper, the strength of the vehicle equipment installation frame and vehicle frame was chosen and the structured to be optimized based on the static analysis, modal analysis and random vibration analysis. The results show that the maximum stress value of the whole structure is 403.41 Mpa under full load condition and the frame frequency does not coincide with the motor frequency and the maximum equivalent stress is 491.36 Mpa in the random vibration analysis. The structure design of the frame and equipment installation frame is reasonable and reliable.