This paper mainly simulates the spinning process of tantalum tungsten alloy liner parts, simulates the spinning process with finite element analysis software, and obtains the stress and strain program in the spinning process. With the wall thickness difference of the spun parts as the analysis target, the influence law of the feed ratio, radius, and working angle of the spinning wheel on the wall thickness difference is obtained. The spinning experiment is conducted with the process parameters obtained from the simulation, and the experimental results are in good agreement with the simulation results, which shows that the method and means of simulation can guide the actual spinning process.