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Perceived Stress is Associated with Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in African Americans with Mild Cognitive Impairment
Antoine R. Trammell, Darius J. McDaniel, Malik Obideen, Maureen Okafor, Tiffany L. Thomas, Felicia C. Goldstein, Leslie M. Shaw, Ihab M. Hajjar
212 - 224
10.3233/AIAD230022
Research Article
Advances in Alzheimer's Disease
Volume 10: Handbook of Prevention and Alzheimer’s Disease
Abstract

Background:

African Americans (AA) have a higher Alzheimer’s disease (AD) prevalence and report more perceived stress than White Americans. The biological basis of the stress-AD link is unclear. This study investigates the connection between stress and AD biomarkers in a biracial cohort.

Objective:

Establish biomarker evidence for the observed association between stress and AD, especially in AA.

Methods:

A cross-sectional study (n = 364, 41.8% AA) administering cognitive tests and the perceived stress scale (PSS) questionnaire. A subset (n = 309) provided cerebrospinal fluid for measurement of Aβ42, Tau, Ptau, Tau/Aβ42 (TAR), and Ptau/Aβ42 (PTAR). Multivariate linear regression, including factors that confound racial differences in AD, was performed.

Results:

Higher PSS scores were associated with higher Ptau (β = 0.43, p = 0.01) and PTAR (β = 0.005, p = 0.03) in AA with impaired cognition (mild cognitive impairment).

Conclusion:

Higher PSS scores were associated with Tau-related AD biomarker indices in AA/MCI, suggesting a potential biological connection for stress with AD and its racial disparity.

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