In this article, the ongoing research on collaborative prototype development between university and enterprises is presented. The study of project featured numerous pilot cases and prototypes, executed in collaboration with organizations to address real-world challenges. This article assesses the appropriateness of the Descriptive Model for Prototyping Process (DMPP) for research project applications. We delve into two primary facets: the synergy between universities and enterprises, and the potential for artifact reusability within the DMPP. The article presents various pilot cases from the KIEMI project, highlighting the DMPP’s role in each. Furthermore, the paper evaluates the model, sets forward the challenges faced, and, finally, discusses topics for future research.