Searching for information on the Web is a crucial activity in which, to obtain relevant results, elements that describe the context of the information must be added. This can be achieved by integrating Semantic Web elements such as ontologies (vocabulary related to a topic) and annotations (descriptions of resources using an ontology) into software systems. This chapter proposes the design and implementation of an ontology in the domain of academic profiles. It also describes the design and implementation of a software system for querying information on academic profiles using the ontology as a knowledge base. The software system consists of two main components: 1) mobile application for the Android platform and 2) web service for access and management of the knowledge base. The academic profiles of the Faculty of Engineering and Sciences of the Autonomous University of Tamaulipas are described as a case study.