China’s chemical industry has developed rapidly, but chemical production safety is still in the primary stage, hazardous chemical fire occurs frequently. The ontology model Hazardous Chemicals Fire Emergency Reaction Ontology (HC-FERO) is constructed on the basis of the knowledge domain and the breadth and depth of ontology. First, ire emergency response upper ontology is constructed with the help of domain experts. Then, a quintuple is established from the aspects of Fire response sequence, response rules, fire extinguishing principle, etc, then we choose protege to generate the hazardous chemical fire emergency ontology. At last, we select the qualitative evaluation to evaluate HC-FERO.