The industrial transition to Industrie 4.0 and subsequently Industrie 5.0 requires robots to be able to share physical and social space with humans in such a way that interaction and coexistence are positively experienced by the humans and where it is possible for the human and the robot to mutually perceive, interpret and act on each other’s actions and intentions. To achieve this, strategies for human- robot interaction are needed that are adapted to operators’ needs and characteristics in an industrial context, i.e., Operator 5.0. This paper presents a research design for the development of a framework for human-robot interaction strategies based on ANEMONE, which is an evaluation framework based on activity theory, the seven stages of action model, and user experience (UX) evaluation methodology. At two companies, ANEMONE is applied in two concrete use cases, collaborative kitting and mobile robot platforms for chemical laboratory assignments. The proposed research approach consists of 1) evaluations of existing demonstrators, 2) development of preliminary strategies that are implemented, 3) re-evaluations and 4) cross-analysis of results to produce an interaction strategy framework. The theoretically and empirically underpinned framework-to-be is expected to, in the long run, contribute to a sustainable work environment for Operator 5.0.