On 6th February 2023, a strong earthquake of magnitude Mw7.8 struck the central and southern parts of Turkey and the northern and western parts of Syria. The epicentre of the earthquake was located approximately 35 km west–northwest of the town Gaziantep, followed by more than 570 strong aftershocks. A strong aftershock measuring Mw 6.7 occurred about 11 minutes after the main shock, while the stronger one (Mw 7.5) around 9 hours later, with an epicenter 95 km to the northeast of the first earthquake. Recorded peak ground accelerations reached 2g, while the vertical acceleration was approximately equal to 1.4g. There was widespread damage with collapsed buildings and countless life loss (humans and animals). The aim of the present paper is to study the response of a nine-story reinforced concrete building (RC), during this seismic sequence. The benchmark building was redesigned with the optimal design of a tuned mass damper (TMD) at the roof of the building. The comparison of the results shows the TMD’s effectiveness in minimizing 50% of the max-story drift, as well as the horizontal displacement in both directions of the building. In addition, the use of the TMD protects the structure from collapse.