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Super-resolution microscopy is considered as an essential tool for imaging biological tissue because it allows resolving tiny structures beyond the diffraction limit of light. However, this technique has certain drawbacks such as the limit of penetration into the tissue, the acquisition speed and the photo-bleaching. Several techniques have been developed to address and solve these problems. We present a super-resolution microscopy technique based on stimulated emission depletion (STED) using compressed detection thanks to the statistical properties of Speckles.