The development of novel measurement schemes usually seeks performance improvements in terms of precision, robustness or speed. Information theory provides tools that allow assessing the maximum precision an estimation procedure can have, thus being a invaluable resource for such developments. Here, I review elements of estimation and information theory —in pragmatic terms— and apply them to MINFLUX single-molecule localization. MINFLUX is a novel localization scheme that utilizes inhomogeneous and dynamic illumination to improve the position estimation precision, reaching isotropic, single nanometer precisions.