This article discusses universal design as a concept and strategy in light of human diversity. Inspired by the German-American philosopher Hannah Arendt, plurality is understood as a condition of humanity. From this recognition of human diversity, the term ‘universal’ is analysed, focusing on the ambivalences inherent in the concept. I argue that universal design, as a human rights concept, must respond to human plurality and avoid the ableist risk of excluding persons and groups of people, when implementing universal design strategies. Interdisciplinary knowledge, education and skills are important for the practice of universal design. According to Article 4 of the Convention On The Rights Of Persons With Disabilities (CRPD), new research is needed to apply universal design strategies in different contexts. I then focus on disabling barriers in education and research. I conclude by arguing for developing a culture of access and embedding universal design strategies in disability research recognising the socio-cultural aspects and human plurality.