DESDEMONA achievements constitute a series of steps beyond the status of knowledge at the EU funded project starting on 1st June 2018, in the development of novel design methods, systems, procedure and technical solution, to integrate sensing and automation technologies for the purpose of self-inspection and self-monitoring of steel structures. The obtained results will lead to an increment of the service life of existing and new steel civil and industrial infrastructure and to a decrease in the cost associated to inspections, improving human activities performed in difficult conditions, safety and workers’ potential by the use of advanced tools. The research succeeded to expand new high-quality standard and practices for steel structure inspection and maintenance through the interrelated development of the following actions: i) steel structure geometry and condition virtualization through data fusion of image processing, thermography and vibration measurements; ii) developing of procedure for steel defect detection by robotic and automatic systems such as Cable-Driven Parallel Manipulators (CDPM), Unmanned Aerial Vehicles (UAV), Wall Climbing Drone (WCD), Cable Climbing Robot (CCR) and Wheeled Robot (WR) iii) embedding sensor systems to revalorize and transform steel elements and structures into self-diagnostic (smart) elements and materials even through nanotechnologies, iv) realizing an experimental lab-based apparatus and a series of case studies inspected by intelligent and robotic systems. The project outcomes are determining an impact on the reduction of the cost of steel structures inspection and maintenance and on the increase of user safety and comfort in industrial and civil environment.