The gasification of COVID-19 plastic waste to methanol was simulated by using Aspen plus software. The effects of main operating parameters on the syngas yield and methanol yield were explored. An industrial Cu/ZnO/Al₂O₃ catalyst was applied for synthetic methanol production, and the relevant kinetic model was built for the methanol synthesis process. The effects of gasification temperature and pressure on the syngas yields and calorific values of syngas and methanol yields from the gasification of medical plastic waste were discussed. The pressure of the synthetic methanol reactor promoted methanol yields, and the external addition of H₂ was optimized for methanol production. It is concluded that the optimal working condition to obtain the highest methanol yield from a suitable HHV of the syngas is when the gasification of plastic waste was carried out at 900 unmapped: inline-formula unmapped: math unmapped: msup unmapped: mrow unmapped: mrow unmapped: mo ∘C under atmospheric pressure with an external H₂ mass flow of 96 kg/hr and the pressure of methanol synthesis at 47 bar.