The role of the field of informatics in medical imaging is vital; novel or adapted informatics’ core methods can be employed to realise innovative information processing and engineering of medical images. As such, imaging informatics can assist in the interpretation of image-based, clinically recorded evidence. This, in turn, leads to the generation of associated actionable knowledge to achieve precision medicine practice. The discipline of informatics has the power to transform data to useful clinical information patterns of observable evidence and, subsequently to generate actionable knowledge in terms of diagnosis, prognosis, and disease management. This paper presents the author’s personal viewpoint and distinct contributions to innovations in the acquisition and collection of imaging data; storage, retrieval, and management of imaging information objects; quantitative analysis, classification, and dissemination of imaging observable evidence.