This volume contains the accepted papers of the International Symposium on Achievements, Milestones, and Challenges in Biomedical and Health Informatics (BMHI) to be held in Athens on October 29, 2022. This is an International Summit event, organised by invitation and attended by the most distinguished colleagues in the field, presenting original review papers in their respective domains with an in-depth, bird’s eye, critical view which also looks in breadth across the timeline of an entire career. It spans an almost forty or even fifty year period that stretches back to the beginnings of the application of computers in health and healthcare, but from a more humble perspective, it can also be seen as just a droplet in the ocean of the scientific history of humanity.

We know that scientific progress is not always linear, and we also understand that, in a similar way, the progress of BMHI may have encountered a few mishaps, delays, failures and enthusiastic expectations, as well as some successes. Each distinguished author in this volume has, from his or her perspective, expertise, region, and background and with humility, attempted to describe the achievements attained, the milestones reached, and the challenges which have been overcome or which we failed to conquer. The Scientific Programme Committee followed all the accepted standards of organising such a Summit event, and each submitted paper was peer reviewed by 3 independent reviewers before being thoroughly revised and submitted to editing and proofreading procedures to maximise the scientific effort of the authors, but also to ensure the high quality of the accepted papers.

I would like to thank my fellow co-editors, Professor Emeritus Arie Hasman and Professor Emeritus Reinhold Haux, for their support during the entire process of organising this Summit event. Without them this event may never have come about. I would also like to thank all reviewers for their challenging work in improving the quality of the papers of the distinguished authors. Finally, I thank Dr. Emmanouil Zoulias for his support in the demanding process of editing the files of the proceedings preparatory to their acceptance by IOS Press.

It should be noted that these Proceedings are published as Open Access, with e-access for ease of use and browsing without the loss of any of the advantages of indexing and citation in the biggest Scientific Literature Databases, such as Medline and Scopus, which the series of Studies in Health Technology and Informatics (HTI) of IOS Press provides. This volume contains 17 high-impact papers in the field of Biomedical and Health Informatics and is dedicated to the entire community of our domain, as well as to the current and the forthcoming students of the discipline wishing to fathom the depth and the timeline of the evolution of BMHI.

The Editor would like to thank the Members of the Scientific Programme Committee, the Organising Committee, and all reviewers, who have performed a very professional, thorough and objective refereeing of the scientific work in order to achieve a high-quality publishing achievement for a remarkable and unique scientific event.

Athens, 18.09.2022

John Mantas, Editor